There are 383.50 miles from San Francisco to Irvine in a southeasterly direction and 421 miles (677.53 kilometers) by car, following route I-5 S. The total driving distance from San Francisco, CA to Irvine, CA is 426 miles or 686 kilometers. Your journey starts in San Francisco, California. The driving distance from Irvine, CA to San Francisco, CA is 426 miles or 686 kilometers.
Your journey begins in Irvine, California. It ends in San Francisco, California. Alternatively, Xe Do Hoang Transportation operates a bus from San Francisco to Westminster, CA once per day.